Scientific Research into Medicinal Cannabis – Osteoporosis & Bone Health

Osteoporosis is a bone disease that occurs when the body loses too much bone, makes too little bone, or both. As a result, bones become weak and may break from a fall or, in serious cases, from sneezing or minor bumps.

Osteoporosis means “porous bone.” Viewed under a microscope, healthy bone looks like a honeycomb. When osteoporosis occurs, the holes and spaces in the honeycomb are much larger than in healthy bone. Osteoporotic bones have lost density or mass and contain abnormal tissue structure. As bones become less dense, they weaken and are more likely to break.

We have listed the latest scientific research into medicinal cannabis and it’s potential uses in treating Osteoporosis & Bone Health

• CBD Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts
• Cannabinoid receptors as target for treatment of osteoporosis: A tale of two therapies
• Cannabinoids and bone: Friend or foe?
• Cannabinoid receptor type 1 protects against age-related osteoporosis by regulating osteoblast and adipocyte differentiation in marrow stromal cells
• Cannabinoids and the skeleton: From marijuana to reversal of bone loss
• The endovanilloid/endocannabinoid system: A new potential target for osteoporosis therapy
• The endovanilloid/endocannabinoid system in human osteoclasts: Possible involvement in bone formation and resorption
• Endocannabinoids and the regulation of bone metabolism
• Cannabinoid receptors and the regulation of bone mass
• Natural products as alternative treatments for metabolic bone disorders and for maintenance of bone health
• Peripheral cannabinoid receptor, CB2, regulates bone mass
• Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors
• Long-chain polyunsaturated fatty acids may mutually benefit both obesity and osteoporosis
• Skeletal lipidomics: Regulation of bone metabolism by fatty acid amide family

 

The Endocannabinoid System and Osteoporosis

• CB1, CB2, TRPV1 and GPR55 receptors are known to be found in the skeleton
• CB1 receptors are found on nerve fibres intervening bone as well as cells in the bone marrow
• CB1 receptors are also found on osteoblasts, osteoclasts and bone marrow derived adipocytes
• Osteoclasts, osteoblasts and osteocytes also express CB2 receptors at significantly higher levels than those reported for CB1

In 2009, there was a group of researchers from the University of Edinburgh (UK) who published a study in the journal Cell Metabolism. Their study suggests that activation of the CB1 receptor is primarily responsible for the benefits of cannabis in treating osteoporosis.

Ayman Idris, Ph. D author of the study said

“the CB1 receptor is therefore unique in that it regulates peak bone mass through an effect on osteoclast activity, but protects against age-related bone loss by regulating adipocyte and osteoblast differentiation of bone marrow stromal cells.”

Eating Healthily helps Osteoporosis

The food that you eat can affect your bones. Learning about the foods that are rich in calcium, vitamin D and other nutrients that are important for your bone health and overall health will help you make healthier food choices every day. If you eat a well-balanced diet with plenty of dairy, fish, fruits and vegetables, you should get enough of the nutrients you need every day, but if you’re not getting the recommended amount from food alone, you may need to complement your diet by taking multivitamins or supplements.

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